CURRICULUM VITAE
Prof. Albert D.M.E. Osterhaus, DVM, PhD
Personal data
Name: Osterhaus
First/other names: Albertus Dominicus Marcellinus Erasmus
Date and place of birth: 02‑06‑1948, Amsterdam
Nationality: Dutch
Scientific education
1961-1967 HBS-B Pius X Lyceum, Amsterdam
1967‑1974 Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
1969 Veterinary candidate (cum laude)
1973 Veterinary doctorate (cum laude)
1974 Graduated as a veterinarian (with honours), Institute of Virology,
Veterinary Faculty, University of Utrecht, The Netherlands
Clinical virology of dogs and cats. Supervisor, Prof.Dr.M.C.Horzinek
1978 Doctoral Thesis (Ph.D.), Veterinary Faculty, University of Utrecht, The
Netherlands: Feline Infectious Peritonitis Virus: Identification,
Propagation and Epidemiology (promotores: Prof.Dr.M.C.Horzinek,
Prof.Dr.J.van Bekkum)
1996 Registered veterinary microbiologist
2001 Educator, Medical Biological Scientific Researcher, specialisation Medical
Microbiology, Stichting Medisch Biologisch Wetenschappelijk Onderzoeker
(SMBWO)
Previous and present positions
1978‑1989 Head of the Section Animal Viruses, National Institute of Public Health and
Environmental Protection (RIVM), Bilthoven, The Netherlands
1978‑1989 Deputy Head of the Unit Control Virus Vaccines, RIVM
1980‑1989 Head of the Section Monoclonal Antibodies, RIVM
1986‑1988 Head of the Section of Immunobiology, RIVM
1986‑1989 Head Section Biochemical Vaccine Controls, RIVM
1982‑1989 Establishment of Laboratory of Immunobiology, RIVM
1988‑1994 Head of the Laboratory of Immunobiology, RIVM
1990‑present Professor of Environmental Virology, State University Utrecht
1993-present Professor of Virology, Erasmus MC, Rotterdam
1993-present Head of the Department of Virology, Erasmus MC, Rotterdam
1993-present Director National Influenza Center (NIC), Rotterdam
1995-2000 Director WHO Global Reference Laboratory for Measles, Rotterdam
2003-present Head WHO National Reference Laboratory for Measles and Rubella with RIVM
Bilthoven, Rotterdam
1995-present Director WHO Collaborating Centre for Arboviruses and Haemorrhagic Fever
Reference and Research, Rotterdam
2007-present Chairman of the Postgraduate School Molecular Medicine Erasmus MC
2009-present Member of the Graduate School Erasmus MC
Professional societies
American Society for Microbiology
Society for General Microbiology
European Scientific Working Group on Influenza
European Society for Veterinary Virology
European Society for Clinical Virology
European Association for Aquatic Mammals
International Association for Aquatic Animal Medicine
Dutch Society for Microbiology
Dutch Society for Laboratory Animal Science
Dutch Society for Immunology
Royal Dutch Society for Animal Science
International Society for Vaccines; Executive committee member
American Society for Virology
European Society of Tropical Medicine and Hygiene
Editorial appointments
1987 – present Associate Editor "Viral Immunology"
1989 Editor "Idiotype Networks in Biology and Medicine", Elsevier Science
Publishers, 1990
1990 Editor "Viral Infections of Vertebrates", Volume "Viral Infections of
Rodents and Lagomorphs", Editor in Chief M.C. Horzinek, Elsevier
Science Publishers
1990 – present Editor "FEMS Immunology/Microbiology"
1991‑2000 Editor "Tijdschrift voor Diergeneeskunde"
1991-2001 Editor "Veterinary Quarterly"
1993 – present European Editor "Vaccine"
1995 – present Editor "Adjuvant Research"
1995-2000 Editor "Journal of General Virology"
1995-1999 Editor "Journal of Medical Primatology"
2001 Editor “Options for the control of influenza IV”, Exerpta Medica,
International Congress Series No. 1219, Elsevier Science BV, Amsterdam
2002 – present Editor “Journal of Clinical Virology”
2005 – present Editor “Medical Microbiology and Immunology”
2005 – present Editorial Board member BMC Microbiology
2005 – present Editor BMC Infectious Diseases
2006 – present Editor Medical Microbiology and Immunology
2008 – present Associate Editor BMC Microbiology
2008 – present Editorial Board member Advances in Virology
2008 – present Advisory Editorial Board member of EMBO Molecular Medicine
2010 – present Co-Editor-in-Chief Current Opinion in Virology
2010 – present Member Editorial Board Infectious Disease
Awards
1985 Schimmel‑Viruly Award: Faculty of Veterinary Medicine, Utrecht
1989 Heine‑Medin Award: European Society against Virus Diseases
1992 Ciba Geigy Prize for Research in Animal Health
1993 Laureate Van Loghem lecture, Dutch Society for Immunology
1995 Firkin Oration, Australian Society for Medical Research
1998 M.W.Beijerinck Virology Award, Royal Dutch Academy of Sciences
2000 UK Royal Society invited lecture on Catastrophes after crossing species barriers
2000 Mulder-Masurel Award on influenza research
2002 The ESCV Gardner Lecture - Viruses emerging from animal reservoirs
2003 Commander in the Order of the Dutch Lion - Royal decoration
2004 James H. Nakano Citation - CDC prize for exceptional scientific publications.
2004 Dr. Saal van Zwanenberg-Oragon prize for exceptional achievement in promoting
scientific research
2004 Reinier de Graaf medal – for exceptional contribution to medicine
2006 Federa prize – for original and exceptional research achievements
2006 European Respiratory Society - European Lung Foundation Award - recognition
of the contribution to the public lung health in Europe
2007 Prix scientifique Louis D - Académie des sciences de l’Institut de France -
research done in the field of transmissible diseases from man to animals,
anthropozoonoses.
2007 Allan Granoff Lectureship in Virology Award, St. Jude's Hospital
2008 Erasmus Award, Erasmus MC Rotterdam, The Netherlands
Selected Special lectures (out of > 1000)
1993 Laurate Van Loghem Lecture, Dutch Society for Immunology
1995 Firkin Oration, Australian Society for Medical Research
2000 UK Royal Society Guest lecture “Catastrophes after crossing species barriers”
2002 The ESCV Gardner lecture “Viruses emerging from animal reservoirs”
2004 UK Royal Society Guest lecture “Characterization of SARS CoV & proof Koch's
postulates”
2004 Guest lecture Annual meeting of the Genootschap tot Bevordering van de
Natuur-, Genees- en Heelkunde
2005 David de Wied Lecture “Rampen door biologisch natuurgeweld in een
veranderende wereld”
2005 Heijermans lecture “Beroepsmatige blootstelling aan dierlijke virussen: Nieuwe
risico's ?”
2006 Eijkman Lecture “Pandemic flu: are we prepared?”
2006 Roy C Anderson Memorial Lecture, University of Guelph
2008 Allan Granoff Lecturer in Virology at St. Jude Children's Research Hospital :
“Emerging virus infections, continuing threat”
2008 Lecture on avian influenza at Jenner Institute Oxford
2008 In Praise of Medicine Lecture: New viruses; a threat from the animal world!
2008 Lecture at 6th ASM Biodefense Emerging Diseases Research Meeting “AIDS,
SARS, bird flu”
2009 Lecture at Seasonal Pandemic Meeting/IDSA on Neuraminidase Inhibitors
2009 Hot topic session at 28th congress of EAACI “Influenza pandemics in the last
centuries”
2009 Late breaker session at ECCMID “Mexican flu: heading for a pandemic?
Patents
US 2001/631966B1 in cooperation with Aventis Pasteur “Induction of rev and tat specific cytotoxic Tcells for prevention and treatment of human immunodeficiency virus (HIV)"
01200213.5 “Human metapneumovirus” – national phase application 2002.
WO 2002/057302(# PCT/NL02/00040)“A virus causing respiratory tract illness in susceptible mammals”
WO 2005/080991 “Method to detect antigen-specific cytolytic activity”
US 2004/0005544 (US Appl. # 10/371.122) “Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of heterologous antigenic sequences”.
US2007087333 Method to detect antigen-specific cytolytic activity, Publication date: 2007-04-19
WO2008061939 Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu.
(Co)‑promotor of Ph.D. students of the Laboratory of Immunobiology (RIVM)/Department of Virology (EUR/EMC)
1988 Thesis Dr.Ir.P.de Vries, University of Utrecht ("Measles virus iscom: A candidate subunit vaccine")
1989 Thesis Dr.E.J.Bunschoten, University of Utrecht ("The immune response to rabies virus idiotypes and regulation")
1990 Thesis Dr.G.F.Rimmelzwaan, University of Utrecht ("Canine parvovirus infection: Novel approaches to diagnosis and immune prophylaxis")
1990 Thesis Dr.V.J.P.Teeuwsen, University of Amsterdam ("Humoral immune response in HIV infection")
1992 Thesis Dr.R.S.van Binnendijk, University of Utrecht ("T cell function in measles. Analysis of T cell responses to measles virus at the clonal level: Antigen processing and presentation")
1993 Thesis Dr.R.W.J.van der Heijden, University of Utrecht ("An idiotypic cascade driven by rabies virus antigen")
1993 Thesis Dr.I.K.G.van der Heijden-Visser, University of Utrecht ("Morbillivirus infections in seals, dolphins and porpoises")
1995 Thesis Dr.A.C.Andeweg, Erasmus University Rotterdam ("Envelope glycoprotein determinants of HIV-1 induced membrane fusion")
1995 Thesis Dr.R.L.de Swart, Erasmus University Rotterdam ("Impaired immunity in seals exposed to bioaccumulated environmental contaminants")
1995 Thesis Dr.P.S.Ross, University of Utrecht ("Seals, pollution and disease: Environmental contaminant-induced immunosuppression")
1995 Thesis Dr.C.H.J.Siebelink, Erasmus University Rotterdam ("Feline immunodeficiency virus: Studies on pathogenesis and vaccine development")
1996 Thesis Dr.J.Groen, Erasmus University Rotterdam ("Hantavirus infections in The Netherlands")
1997 Thesis Dr.M.Schutten, Erasmus University Rotterdam ("Antibody mediated neutralization and enhancement of HIV-1 infection")
1997 Thesis Dr.A.M.Geretti, Erasmus University Rotterdam ("Role of cytotoxic T lymphocyte responses in the control of primate immunodeficiency viruses")
1997 Thesis Dr.E.J.Tijhaar, Erasmus University Rotterdam ("Lentivirus vaccine development. Antigen presentation by Salmonella and iscom")
1997 Thesis Dr.T.C.Harder, Erasmus University Rotterdam ("Herpesviruses and morbilliviruses of aquatic and terrestrial carnivores")
1997 Thesis Dr.E.G.J.Hulskotte, Erasmus University Rotterdam ("HIV-1 vaccine development: Studies in macaque models")
1998 Thesis Dr.I.J.T.M.Claassen, Erasmus University Rotterdam ("Immunogenic presentation of viral and bacterial antigens: Iscom and OMV as a basis for new vaccines")
2000 Thesis Dr.M.E.van der Ende, Erasmus University Rotterdam (“HIV-2: pathogenesis and antiretroviral therapy”)
2000 Thesis Dr.A.H.Brandenburg, Erasmus University Rotterdam (“Respiratory syncytial virus infections in infants. Determinants of clinical severity”)
2000 Thesis Dr.J.T.M.Voeten, Erasmus University Rotterdam (“Influenza. New vaccines and antiviral immunity”)
2001 Thesis Dr.K.J.Stittelaar, Erasmus University Rotterdam (“Vaccination against measles. Evaluation of novel approaches”)
2001 Thesis Dr.P.P.Heinen, University of Utrecht (“Protective immunity against influenza in pigs”)
2002 Thesis Dr.C.A.van Baalen, Erasmus University Rotterdam (“Capacity of cytotoxic T lymphocytes to control the reproduction of human immunodeficiency virus”)
2002 Thesis Dr.L.Remeijer, Erasmus University Rotterdam (“Human herpes simplex virus keratitis: The pathogenesis revisited”)
2002 Thesis Dr.J.Maertzdorf, Erasmus University Rotterdam (“Pathogenesis of herpes simplex virus infections of the cornea”)
2003 Thesis B.Martina, University of Utrecht (“Seal herpesviruses: Characterisation, host susceptibility and vaccine development”)
2003 Thesis Dr. A.C.M. Boon, Erasmus MC Rotterdam (“Cytotoxic T Lymphocyte Mediated Immunity to Influenza”)
2003 Thesis Dr. L. de Waal, Erasmus MC Rotterdam (“Respiratory Syncytial Virus Anti-viral immunity in humans and macaques”)
2004 Thesis Dr. I. Van Benten, Erasmus MC Rotterdam (“Viral respiratory infections and the development of the immune response in the nose of young children: the VIGALL study)
2004 Thesis Dr. M. Barends, Erasmus MC Rotterdam (“Respiratory Syncytial Virus (RSV) and Asthma”)
2004 Thesis Dr. B. van den Hoogen, Erasmus MC Rotterdam (“Human Metapneumovirus. Discovery, Characterisation and Associated Disease”)
2006 Thesis Dr. A.T.A. Mairuhu, Radboud University Nijmegen (“Studies on clinical and pathophysiological aspects of dengue virus infection”)
2006 Thesis Dr. V. Munster, Erasmus MC Rotterdam (“Ecology, Evolution and Pathogenesis of Avian Influenza Viruses”)
2006 Thesis Dr. E. de Wit, Erasmus MC Rotterdam (“Molecular determinants of influenza A virus replication and pathogenesis”)
2007 Thesis Dr. E.G.M. Berkhoff, Erasmus MC Rotterdam (“ Evasion from human T cell immunity by influenza A viruses”)
2007 Thesis Dr. P. Koraka, Erasmus MC Rotterdam (“Dengue virus specific immune response: implications for laboratory diagnosis and vaccine development”)
2007 Thesis Dr. J. Philippa, Erasmus MC Rotterdam (“Vaccination of non-domestic species against emerging infectious diseases”)
2008 Thesis Dr. S. Herfst, Erasmus MC Rotterdam (“Towards a human metapneumovirus vaccine")
2008 Thesis Dr. S. Noppornpanth, Erasmus MC Rotterdam (“Genetic diversity and molecular evolution of Hepatitis C Viruses”)
2008 Thesis Dr. J.M. Rijks, Erasmus MC Rotterdam(“Phocine Distemper Revisited”)
2008 Thesis Dr. W. Huisman, Erasmus MC Rotterdam (“FIV Vaccine Development: A Continuing Challenge”)
2009 Thesis Dr. M. de Graaf, Erasmus MC Rotterdam (“Metapneumovirus: determinants of host range and replication”)
2009 Thesis Dr. C. Geurts van Kessel, Erasmus MC Rotterdam (“Division of Labor between dendritic cell subsets in the lung during influenza virus infection”)
2009 Thesis Dr. R. Duan, Erasmus MC Rotterdam (“Herpetic Keratitis in Humans: Interaction between virus and host”)
2009 Thesis Dr. J. Kreijtz, Erasmus MC Rotterdam ("Protection against influenza A(H5N1) induced by influenza A(H3N2) infection and MVA-based vaccines")
Consultancies
1980‑2000 European Veterinary Laboratory (EVL), Amsterdam, The Netherlands
1982-1986 Evaluator of project proposals Dutch Asthma Fund
1984‑2000 ISCOTEC AB, Uppsala, Sweden
1986-1988 Member Evaluation Committee Public Health Council (GHR) project proposals
Monoclonal Antibodies
1988‑1989 WHO consultation on polio eradication
1988‑present EC Project Management Group Basic Research AIDS
1988-present Member Evaluation Committee project proposals RGO/PccAO AIDS Research
1988‑present Veterinary Advisory Committee Seal Rehabilitation and Research Centre,
Pieterburen, The Netherlands
1989‑present Scientific Advisory Committee Seal Rehabilitation and Research Centre, Pieterburen, The Netherlands (chairman)
1989-1999 International Scientific Advisory Committee of the Hellenic Society for the Study and Protection of the Monk Seal (chairman)
1989-1992 National Co-ordinator of the European Society for Veterinary Virology
1989 Member Evaluation Committee project proposals EC program "BRIDGE - Animal Husbandry"
1989 EC Working Party on Bovine spongiforme encephalitis (BSE)
1990‑1996 WHO Steering Committee on Measles/Acute Respiratory Viruses and Poliomyelitis (chairman)
1990-present Member/project leader several NWO-GMW (Evaluation) Committees (Co-ordination AIDS research, Vaccines, Immune Physiology and immune pathology, Histocompatibility and Transplantation, Immune regulation, Persistent virus infections and oncogenic transformations)
1991‑present WHO Task Force Measles
1991‑present Marine Environmental Research Institute Advisory Board
1991‑present EC Scientific Veterinary Committee, Section Public Health and several subcommittees
1991‑present International Union for Conservation of Nature and Natural Resources, Species Survival Commission (IUCN/SSC)
1991-1993 Member of the RIVM Committee Alternatives for Animal Experiments
1991-1996 External Advisor of the Center for AIDS Research (CFAR), San Antonio, USA
1992-present Committee Experts Immunization Soldiers (CDIM), Ministry of Defense
1992-present Member several Evaluation Committees for project proposals in the EC Programs on Biotech and Biomed
1992 Member Site Visit Committee, Central Veterinary Institute (CDI), Lelystad
1994-1995 EC Biotechnology Ad Hoc Review Group on Transdisease Vaccinology
1994 EC Expert Committee Member for the ISTC on Safety aspects of vaccine development and production in Novosibirsk, Russia
1995-present Member of the Committee for Infection and Immunity of the Dutch Health Council
1995-present Member Council of Europe, European Pharmacopoeia Commission, Ad Hoc Working Group "Quality of biologicals obtained from warm blood animals"
1995-present Non-voting advisor Dutch Health Council
1995-present Member EC Task Force Vaccines and Viral Diseases
1995-present Member of the Council of the European Society for Clinical Virology (ESCV)
1995 Member NIH-NIAID special review committee for the evaluation of applications on "Research on Hantavirus and Other Emerging Viral Threats" (RFA 95-13)
1996 Chairman of the Committee for Prion Diseases of the Dutch Health Council
1996-present Member of the Scientific Advisory Committee of the International AIDS Vaccine Initiative
1996-2000 Member of Imutran's Safety Advisory Board on Xenotransplantation
1996-1997 Member of the Committee on Xenotransplantation of the Dutch Health Council
1996-present Member of the International Board for Swedish Infection & Vaccinology network, Foundation of Strategic Research
1997-present Evaluator of the German Federal Ministry of Education, Science, Research and Technology (BMBF) for several research priorities
1997‑present Member of the EC Scientific Steering Committee (vice chairman since 2000)
1997-2000 Chairman of the EC Scientific Committee on Veterinary Measures relating to Public Health
1997-present Member of the EC Scientific Steering Committee ad hoc group on TSE/BSE
1997-present Member of the European Scientific Working Group on Influenza (ESWI) (vice chairman since 2000)
1997-present Member "Hollandsche Maatschappij der Wetenschappen"
1998-present Member of the International Scientific Advisory Board of the Graduate School Animal Health (GSAH), Utrecht University
1998-2001 Chairman of the Committee on "The use of leuco-depletion of donor blood" of the Dutch Health Council
1998-present Evaluator of The Wellcome Trust for several research priorities
1999-2002 Member of the Scientific Advisory Committee of the Landsteiner Foundation for Bloodtransfusion Research
1999-present Member of the Scientific Advisory Board of the Central Laboratory of the Blood Transfusion Service of the Dutch Red Cross (CLB)
1999-present Advisor CCMO (Central Committee Human-bound Research) on Xenotransplantation
2000-2008 Member of the Board of Supervisors of the Foundation Royal Rotterdam Zoo Blijdorp
2000 External expert advisor to the Food Standards Agency review of BSE controls, London, UK
2000-2007 Member Scientific Advisory Committee for the Beijerinck Virology Fund, Royal Dutch Academy of Sciences (Chairman 2001)
2000-2001 Member of the Committee on "Bioterrorism" of the Dutch Health Council
2000-present Board member ISCONOVA AB, Sweden (veterinary company)
2000-2009 Director ViroClinics BV, Rotterdam, The Netherlands (EUR holding)
2000-present Member Evaluation Committee of the (Retro-)virology Department at Institute Pasteur, Paris, France
2001 Member of the Scientific Advisory Committee of the Netherlands ME Foundation
2001 Member Evaluation Committee of Applications in the Finnish Programme for Centres of Excellence in Research 2002-2007
2001-present Member of the "Koninklijke Nederlandse Akademie van Wetenschappen" (Royal Dutch Academy of Sciences)
2001-present Member of the Standing Executive Committee of the International Society for Vaccines
2001-2004 Chairman Board of Supervisors of Vaxinostics BV
2002 Member Temporary Committee on Foot-and-Mouth Disease of the European Parliament
2002‑present Member of the Board of Supervisors of the Seal Rehabilitation and Research Centre, Pieterburen, The Netherlands
2002-present Member National (RGO) Committee on Infectious Diseases
2002-present Member "Bataafsch Genootschap der Proefondervindelijke Wijsbegeerte"
2002-present Member WHO Product Development Group for Aerosol Measles Vaccine
2002-present Member Board of Professors, Erasmus University Rotterdam
2003-present Member of the EC Scientific Committee on Veterinary Measures relating to Public Health ad hoc working group on West Nile Virus
2003-present Member of WHO SARS aetiology network
2003-present Member of the Advisory Committee to the Vaccine Research and Development Center in National Health Research Institutes Taiwan
2004-present Member of the Scientific Advisory Council AIDS Fund
2004-2008 Member EDBR/OBR (Economic Development Board Rotterdam)
2004-2008 Chairman Taskforce Medical Cluster EDBR/OBR (Economic Development Board Rotterdam)
2005-present Defra Science Advisory Council Epidemic Diseases Sub-group (SAC-ED)
2005-present Royal Society Pandemic Influenza Working Group
2005-present European Centre for Disease prevention and Control (ECDC) roster of scientists
2005-present Dutch Food and Consumer Product Safety Authority
2005-2008 Member Institut Pasteur Hong Kong Scientific Advisory Board
2005-present Member Institut Pasteur Singapore Scientific Advisory Board
2006-present Member Safe Foods Scientific Panel (EFSA)
2006-present Member Animal Health and Welfare Working Group (EFSA)
2006-present Member Jung-Stiftung für Wissenschaft und Forschung
2006-present Member Erfocentrum Scientific Advisory Board Medical Biotechnology Project
2006-present Member WHO Influenza Pandemic Taskforce
2006-present Member EASAC Werkgroep over Zoonoses
2006-present Member SAB Octoplus B.V.
2007-present Member SAB Pevion Biotech
2007-2009 Panel Chair ERC Advanced Grant Panel LS6: Immunity and infection
2008-present Member International Scientific Advisory Board of the Jenner Institute
2008-present Member WHO Strategic Advisory Group of Experts (SAGE)
2008-present Chairman Institut Pasteur Hong Kong Scientific Advisory Board
2008-present Member of the WHO International Health regualtions (2005) Roster of Experts
2008-present Member Expert Assessment Panel for MRC Multidisciplinary Centre of Excellence for Virology Research
2008-present Member WHO Advisory Sub-Committee on Variola Virus Research
2008-present Voorzitter School of Molecular Medcine Erasmus MC Rotterdam
2009-present Scientific advisor Viroclinics Biosciences BV. The Netherlands (EUR holding0
2009-present Member SystemsX.ch Advisory Board
2009-present Honorary member of the European Society for Intensive Care Medicine
Consultancies commercial companies
Crucell
Intervet/Nobilon
MedImmune
Octoplus
Pevion
Pharmathene
Roche
Solvay
GSK
Establishment of Biotech companies (CEO/CSO)
2000-2009 Viroclinics B.V.
2009-present Viroclinics Biosciences B.V.
2001-2008 Vironovative B.V.
2003-2008 Coronovative B.V.
(Co-)organiser/board member meetings, since 1996
- 2nd World Congress on Alternatives and Animal Use in the Life Sciences, 20-24 October 1996, Utrecht, The Netherlands
- Conference 25 years virology in Rotterdam, 11 October 1996, Rotterdam, The Netherlands
- 13th European Immunology Meeting, 22-25 June 1997, Amsterdam, The Netherlands
- Winter meeting of the European Society for Clinical Virology (ESCV), 7-9 January 1999, Rotterdam, The Netherlands
- Berne/Solvay Meeting on European Perspectives in the Control of Infectious Diseases, 16-17 April 1999, Malta
- European Network for Diagnostics of Imported Viral Diseases (ENIVD) meeting, 3-5 June 1999, Rotterdam, The Netherlands
- 10th International Congress of Mucosal Immunology, 27 June-1 July 1999, Amsterdam, The Netherlands
- International Congress “Sexually Transmitted Diseases in a Changing Europe”, 13-15 April 2000, Rotterdam, The Netherlands
- European Scientific Working Group on Influenza (ESWI) Spring Meeting, 3-4 May 2000, Rotterdam, The Netherlands
- Co-ordinator International Programme Committee of the “Options for the Control of Influenza IV” meeting, 23-28 September 2000, Crete, Greece
- Stakeholders meeting on pandemic influenza, 27 November 2001, Brussels, Belgium
- IV International Symposium on Respiratory Viral Infections, 30 November- 2 December 2001, Curaçao, Antilles
- Scientific Meeting on "Management of Influenza" (Retroscreen), 5 May 2002, Paris, France
- Chairman at the First European Influenza Conference, 20-23 October 2002, St. Julians, Malta
- ECEAR 2002, 2002, Genoa, Italy
- “Options for the Control of Influenza V” meeting, 7-11 October 2003, Okinawa, Japan
- Viral Vaccine Meeting, 25-28 October 2003, Barcelona, Spain
- 12th International Congress of Immunology, 18-23 July 2004, Montréal, Canada
- Vaccine Development Symposium, 17 March 2005, Rotterdam, The Netherlands
- Second European Scientific Working Group on Influenza (ESWI) Meeting, 11-14 September 2005, St. Julians, Malta
- Member Local Organising Committee IAVI AIDS Vaccine meeting, 29 August-1 September 2006, Amsterdam, The Netherlands
- Member Scientific Advisory Board Influenza Vaccines for the World Congress, 18-20 October 2006, Vienna, Austria
- Member of International Advisory Board World Congress on Vaccines, Immunisation and Immunotherapy Conference, 4-6 November 2006, Montreal, Canada
- Keystone Symposium on Respiratory Viruses of Animals Causing Disease in Humans, Singapore 10-15 December 2006
- Member National Host Committee World Congress on Vaccines, Immunisation and Immunotherapy Conference, The Hague, 2008
- Third European Scientific Working Group on Influenza (ESWI) Meeting, 14 –17 September 2008, Villamoura Portugal
- XI International Symposium on Respiratory Viral Infections, February 19-22, 2009, Bangkok, Thailand
- Member organizing Committee ERS, Vienna, Austria 24 October 2009
Clinical Trials
1994 Principal Investigator in: GMDP as adjuvant to Influvac subunit vaccine. Immunogenicity and reactogenicity of adjuvant GMDP orally administered just prior to vaccination with a trivalent influenza subunit vaccine. A double-blind placebo controlled study in nursing home residents.
1994 Principal Investigator in: a double-blind, randomised, placebo-controlled, parallel-group, multicentre study to investigate the efficacy and safety of inhaled and intranasal GG167 in the treatment of Influenza A and B viral infections.
1995 Principal Investigator in: a double-blind, randomised, placebo-controlled, multicentre parallel-group study to investigate the efficacy and safety of GG167 administered twice or four times a day for the treatment of Influenza A and B viral infections.
1996 Principal Investigator in: a double-blind, randomised, placebo-controlled, parallel-group, multicentre study to investigate the efficacy and safety of inhaled zanamivir (GG167) 10 mg administered twice a day for five days in the treatment of symptomatic Influenza A and B viral infections in adolescents and adults.
1997 Principal Investigator in: a randomised, double-blind study to determine the cell-mediated and humoral immunogenicity of two influenza ISCOM™ vaccines (type I and II) versus Fluvax® (inactivated influenza vaccine split virion) in young healthy adults.
1997 Principal Investigator in: a double blind, randomised, placebo-controlled study of Ro 64-0796 (also known as GS 4104) used for the prevention of clinical influenza post exposure.
1998 Principal Investigator in: a double blind, randomised, placebo-controlled study of Ro 64-0796 (also known as GS 4104) used for the treatment of influenza infection.
1998 Principal Investigator in: a double blind, randomised, placebo-controlled study of Ro 64-0796 (also known as GS 4104) in the treatment of influenza in children with chronic asthma.
1998 Principal Investigator in: a single center, single-blinded placebo-controlled study of a recombinant RSV vaccine in the treatment of severe lower respiratory tract infection.
1999 Investigator in: immunogenicity and tolerability of three dosages of an anti RSV vaccine, administered in an ambulant elderly adult population over 60 years old.
1999 Investigator in: a double blind, randomised, placebo-controlled study of RWJ 270201 for the treatment of influenza infections in healthy subjects.
2000 Investigator in: a double blind, randomised, placebo-controlled study of RWJ 270201 for the treatment of influenza infections in asthmatic subjects.
2006 PI in an autologous DC vaccination study in HIV infected humans.
Co-ordinator of projects
Principle investigator/co-ordinator major collaborative projects, since 1996:
European Union
1996
Elimination of measles from East Africa
k€ 220
1997
Antibody mediated enhancement of lentivirus infections
k€ 150
1998
Molecular mechanisms underlying HIV entry
k€ 120
1998
Post-exposure vaccination against hepatitis B
k€ 200
1999
Treatment of hepatitis C infection
k€ 220
2000
Hepatitis C vaccine efficacy against S.E. Asian genotypes
k€ 250
2000
IMPRESSUVAC (RSV immunopathogenesis)
k€ 500
2002
HAMMOCS 9human/animal metapneumovirus)
k€ 470
2002
NOVAFLU (vaccination against pandemic influenza)
k€ 545
2004
NIVAREC (Development of novel influenza vaccines in the
face of pandemic threat)
k€ 1350
2004
COMPUVAC Rational design and standardized evaluation of novel
genetic vaccines
k€ 438
2004
DISSECT Development of intervention strategies against SARS in a European-Chinese Taskforce
k€ 390
2006
NEW-FLUBIRD (Network for early warning of influenza viruses in
migratory birds in Europe)
k€ 185
2008
EMPERIE (European Management Platform for Emerging and Reemerging
Infectious disease Entities)
k€ 1920
NIH
2000
Protective capacity of HIV early protein specific CTL
k€ 350
2006
SARS
k€ 850
2009
Animal Models of Infectious Diseases
pending
NWO-BSIK
2004
VIRGO - Genomics and respiratory viruses
K€2300
2009
VIRGO II
pending
2009
FES 2009, research line viral infections
pending
WHO
2000
Novel generations of measles vaccines
k€ 100
2001
Aerosol vaccination against measles
k€ 120
2002
Efficacy and Safety of a Tetravalent Dengue Vaccine in a Macaque
Model
k€ 140
Industry
1997
Influenza: high through-put viruses
k€ 150
1997
FIV vaccine
k€ 600
1997
FIV vaccine development
k€ 1100
1997
Influenza iscom
k€ 185
1998
Candidate RSV vaccine clinical trial
k€ 1100
1998
Genital herpes pathogenesis
k€ 160
1999
Bioactive food components
k€ 180
1999
High-growth reassortant influenza virus
k€ 125
1999
Influenza response modifiers
k€ 400
1999
High growth reassortant influenza
k€ 100
1999
T cells in herpes genitalis
k€ 35
1999
Flu in a monkey model
k€ 145
1999
Neuraminidase inhibitors clinical trial
k€ 500
2002
Rev and Tat vaccination
k€ 2000
Foundations etc.
1997
HLA class I restricted CTL in hepatitis C pathogenesis
k€ 115
1998
Intraocular T cells
k€ 150
1998
Intraocular HSV specific T cells
k€ 333
1998
Local cellular immune response in RSV pathogenesis
k€ 95
1999
CTL against early vs. late HIV proteins
k€ 260
1999
HBV and HCV co-infections in AIDS
k€ 70
1999
AIDS vaccine development
k€ 579
1999
Phage display technology
k€ 110
2000
ADE and neutralisation in AIDS pathogenesis
k€ 60
2001
Dendritic cell exosomes in therapeutic immunisation
k€ 200
2002
Newly discovered human metapneumovirus
k€ 120
2006
Development of resistance towards antivirals in herpetic keratitis
k€ 150
Identification of viral pathogens
1977 First non‑mammalian papillomavirus: Finch papilloma virus
1978 First demonstration of canine parvovirus in The Netherlands
1981 First demonstration of mouse pox in The Netherlands
1984 First phocid herpesvirus (phocid herpesvirus‑1): high mortality in young seals
1988 First phocid morbillivirus (phocid distemper virus, PDV): cause of mass mortality in seals
1988 First picornavirus in seals (affected by PDV infection)
1989 First demonstration of Hantavirus infections in humans and rodents in The Netherlands
1990 First Orthopoxvirus in seals (affected by PDV infection)
1992 Porpoise and dolphin morbilliviruses causing mortality in cetacean species
1992 Rhabdovirus of dolphins
1994 Parapoxvirus in grey seals
1995 Hepatitis B virus infection in heart transplant patients in the Dijkzigt Hospital Rotterdam
1995 Identification of CDV as cause of mass mortality in Serengeti lions
1996 Identification of a g-herpesvirus in seals (phocid herpesvirus-2)
1997 Identification of monk seal morbilliviruses (MSMV-WA/G)
1997 Identification of influenza A (H5N1) virus in humans
1998 Identification of a lentivirus from Talapoin monkeys (SIVtal)
1999 Identification of influenza B virus in seals
2000 Identification of measles virus re-introduction in The Netherlands
2000 Identification of human metapneumovirus (hMPV) as a new member of the genus Metapneumovirus
2002 Identification of re-emerging PDV in Europe
2002 Presence of hantavirus infection in Indonesia
2002 Presence of hantavirus infection in Barbados
2003 Identification of coronavirus as the primary cause of SARS
2003 Identification of influenza A (H7N7) virus in humans
2004 Identification of fourth human coronavirus
2005 Identification of H16 influenza A viruses in black headed gulls
More than 850 papers in peer reviewed journals and numerous others (book chapters etc)