Prof. Dr. Bruno Gottstein
Director Institute of Parasitology
Vetsuisse Faculty and Faculty of Medicine
University of Berne
Brief Curriculum Vitae
(updated spring 2010)
Biographical
Gottstein, Bruno (born March 22, 1954)
Working address: Institute of Parasitology of the Faculty of Veterinary Medicine and the Faculty of Medicine, University of Bern, Länggass-Strasse 122
CH-3012 Bern / Switzerland
EDUCATION
• 1974–1979: Study of Medical Microbiology, University of Bern
• 1979: Diploma in Medical Microbiology; 1981 Ph.D., University of Bern
• 1991: Habilitation (Privatdozen)t in Veterinary and Medical Parasitology, University of Zürich
• since 1992: full professorship (Ordinarius) in Veterinary and Medical Parasitology, University of Berne
• 2004: CBA (Certificate in Business Administration), Universities of Fribourg and Trier
• 2004: AssEVPC (European Veterinary Parasitology College)
PRESENT INVOLVEMENT IN PARASITOLOGY
Presently running Research Supports
Research Grant, for “Assessment of efficacy and efficiency of toltrazuril-treatment in newborn mice from Neospora-positive dams”, from Bayer Animal Health (2005–20012).
Research Grant, for “Echinococcus multilocularis and alveolar echinococcosis: the molecular struggle“, from the Swiss National Science Foundation, prolongation project No. 3100AO-111780 (2009-2012).
Research Grant, for “Toxoplasma gondii: Prevalences and Sources of infection in Switzerland“, from the Swiss Federal Veterinary Office (2007-2010).
Research Grant, for “Molecular and epidemiological invetigations on Naegleria fowleri and other neurotropic free-living amoebae”. FOCP-Project (2008-2012).
-> Additional smaller research support grants have been provided by various Institutions, private Foundations, EU-related sources for the whole working periods (list available upon request).
Awards
• "1989 Förderungspreis" of the Swiss Society of Microbiology, Switzerland, 1989
• "Behring-Bilharz-Preis", Berlin, Germany, 1993
• Honorary Member of the Bulgarian Society of Parasitology, 2004
• Member of the “Deutsche Akademie der Naturforscher Leopoldina”, 2006
PUBLICATION LIST (years 2007 – 2010)
(in alphabethical order; for former years, request separate list)
1. Alzieu JP, Cortes H, Gottstein B, Jacquiet Ph, Dorchies Ph, Schelcher F, L’hostis M B: La besnoitiose bovine: actualités épidémiologiques et diagnostiques. Bulletin des GTV; HSPDB: 41-49 (2007).
2. Alzieu JP, Dochies P, Schelcher F, Gottstein B: L’extension de la besnoitiose bovine en France. Le Point Vétérinaire, 38: 37-43 (2007).
3. Arsenijevic D, de Bilbao F, Vallet P, Hemphill A, Gottstein B, Richard D, Giannakopoulos P, Langhans W: Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii. Neuroschience 150: 537-46 (2007).
4. Badaraco JL, Ayala FJ, Bart JM, Gottstein B, Haag KL. Using mitochondrial and nuclear markers to evaluate the degree of genetic cohesion among Echinococcus populations. Exp Parasitol. 119: 453-459 (2008).
5. Ben Nouir N, Gianinazzi C, Gorcii M, Müller N, Nouri A, Babba H, Gottstein B: Isolation and molecular characterization of recombinant Echinococcus granulosus P29 protein (recP29) and its assessment for the post-surgical serological follow-up of human cystic echinococcosis in young patients. Trans Roy Soc Trop Med. Hyg 103: 355-364 (2009).
6. Ben Nouir N, S. Nunez, C. Gianinazzi, M. Gorcii, N. Müller, A. Nouri, H. Babba, B. Gottstein: Assessment of Echinococcus granulosus somatic protoscolex antigens for the serological follow-up of young patients surgically treated for cystic echinococcosis. J Clin Microbiol 46:1631-1640 (2008).
7. Ben Nouir N, S. Nuňez, E. Frei; M. Gorcii, N. Müller, C. Gianinazzi, M. Mekki, A. Nouri, H. Babba, B. Gottstein: Post-surgical follow-up (by ELISA and immunoblotting) of cured versus non-cured cystic echinococcosis in young patients. Parasitology 135: 105-14 (2007)
8. Burger N, Busato A, Nesvadba J&Z, Gottstein B: Epidemiologische Untersuchungen zum Vorkommen von Dicrocoelium dendriticum im Emmental. Berl. Münch. Tierärztl. Wochenschr. 119: 324-329 (2006).
9. Burgerner IA, Frey CF, Kook PH, Gottstein B: Tritrichomonas fetus: ein neuer Parasit im Darm von Schweizer Katzen. Schweiz. Arch. Tierheilk. 151: 383- 389.
10. Casulli A, Bart JM, Knapp J, La Rosa G, Prosl H, Gottstein B, Manfredi MT, Genchi C, Piarroux R, Pozio E: Multi-locus microsatellite analysis supports the hypothesis of an autochthonous focus of Echinococcus multilocularis in northern Italy. Int J Parasitol 39: 837-842 (2009).
11. Cortes H, Nunes S, Reis Y, Staubli D, Vidal R, Sager H, Leitão A, Gottstein B: Improved immunodiagnosis of Besnoitia besnoiti-infection in cattle by the use of ELISA and Westernblot. Vet Parasitol. 141: 216-225 (2006).
12. Cortes HC, Reis Y, Gottstein B, Hemphill A, Leitao A, Muller N. Application of conventional and real-time fluorescent ITS1 rDNA PCR for detection of Besnoitia besnoiti infections in bovine skin biopsies. Vet Parasitol. 146: 352-356 (2007).
13. Frey CF, Buhalzer P, Beck R, Marinculic A, Raeber AJ, Gottstein B, Schuppers M: Evaluation of a new commercial enzyme-linked immunosorbent assay for the detection of porcine antibodies against Trichinella spp.. J Vet Diagn Invest 21:692-697 (2009).
14. Frey CF, Schild M, Hemphill A, Stünzi P, Müller N, Gottstein B, Burgener IA. Intestinal Tritrichomonas foetus infection in cats in Switzerland detected by in vitro cultivation and PCR. Parasitol Res. 104: 783-788 (2009).
15. Frey CF, Schuppers ME, Müller N, Ryser-Degiorgis MP, Gottstein B: Assessment of the prevalence of Trichinella spp. in red foxes and Eurasian lynxes from Switzerland. Vet Parasitol. 159 :295-299 (2009).
16. Frey CF, Schuppers ME, Müller N, Ryser-Degiorgis MP, Gottstein B: Assessment of the prevalence of Trichinella spp. in red foxes and Eurasian lynxes from Switzerland. Vet Parasitol. 159 :295-299 (2009).
17. Frey CF, Schuppers ME, Nöckler K, Marinculić A, Pozio E, Kihm U, Gottstein B: Validation of a Western Blot for the detection of anti-Trichinella spp. antibodies in domestic pigs. Parasitol Res. 104: 1269-1277 (2009).
18. Frey CF, Schuppers ME, Nöckler K, Marinculić A, Pozio E, Kihm U, Gottstein B: Validation of a Western Blot for the detection of anti-Trichinella spp. antibodies in domestic pigs. Parasitol Res. 104: 1269-1277 (2009).
19. Gianinazzi C, Schild M, Wüthrich F, Ben Nouir N, Füchslin HP, Schürch N, Gottstein B, Müller N: Screening Swiss water bodies for potentially pathogenic free-living amoebae. Res Microbiol. 160: 367-374 (2009).
20. Gianinazzi C, Schild M, Wüthrich F, Müller N, Schürch N, Gottstein B: Potentially human pathogenic Acanthamoeba isolated from a heated indoor swimming pool in Switzerland. Exp Parasitol. 121:180-186 (2009).
21. Gottstein B, Hemphill A: Echinococcus multilocularis: The parasite-host interplay. Exp Parasitol. 119: 447-452 (2008).
22. Gottstein B, Pozio E, Nöckler K: Epidemiology, Diagnosis, Treatment, and Control of Trichinellosis. Clin Microbiol Rev, 22:127–145 (2009).
23. Gottstein B, Reichen J: Echinococcosis/Hydatidosis. In: Manson’s Tropical Diseases, 22nd edition, eds. GC Cook and AI Zumla, Saunders Elsevier Ltd., chapter 86, pp 1549-1568 (2009).
24. Gottstein B, Schuppers M: Trichinellosis: crossing the Chinese wall. The Vet. J. 173:243-244 (2007).
25. Gottstein B, Wittwer M, Schild M, Merli M, Leib SL, Müller N, Müller J, Jaggi R. Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS One. 2010 Apr 1;5(4):e9779.
26. Gottstein B: Etat actuel des connaissances sur la néosporose bovine. Bulletin des GTV; HSPDB: 37-40 (2007).
27. Gottstein B: Hydatid Disease. In In: Infectious Diseases, 3rd edition (eds. Armstrong D, Cohen J). Vol. II, Chapter XX, pp. x-x. Mosby, London (2010, in press).
28. Gottstein B: Neospora caninum e neosporosi. Large Animal Review 14:23-25 (2008).
29. Gottstein B: Neospora: Hunde sind selten Schuld. DLZ Agrarmagazin; 8: 91-93 (2007).
30. Graichen DA, Gottstein B, Matsumoto J, Muller N, Zanotto PM, Ayala FJ, Haag KL. Expression and diversity of Echinococcus multilocularis AgB genes in secondarily infected mice: evaluating the influence of T-cell immune selection on antigenic variation. Gene 392: 98-105 (2007).
31. Haag K, Gottstein B, Ayala FJ: Taeniid history, natural selection and antigenic diversity: evolutionary theory meets helminthology. Trends in Parasitology, 24: 96-102 (2008).
32. Haag KL, Gottstein B, Ayala FJ: The EG95 antigen of Echinococcus spp. contains positively selected amino acids, which may influence host specificity and vaccine efficacy. PLoS ONE 4(4): e5362. doi:10.1371/journal.pone.0005362 (2009).
33. Haag KL, Gottstein B, Ayala FJ. The EG95 antigen of Echinococcus spp. contains positively selected amino acids, which may influence host specificity and vaccine efficacy. PLoS One. 2009;4(4):e5362. Epub 2009 Apr 29.
34. Haesler B, Staerk K, Gottstein B, Reist M: Epidemiologische und finanzielle Entscheidungsgrundlagen zur Kontrolle von Neospora caninum auf Schweizer Milchviehbetrieben. SAT 150: 273-280 (2008).
35. Hemphill A, Spicher M, Stadelmann B, Mueller J,Naguleswaran A, Gottstein B, Walker M. Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134: 1657-1670 (2007).
36. Hemphill A, Stadelmann B, Scholl S, Müller J, Spiliotis M, Müller N, Gottstein B, Siles-Lucas M. Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology. 2010 Mar;137(3):569-87.
37. Knapp J, Bart JM, Giraudoux P, Glowatzki ML, Breyer I, Raoul F, Deplazes P, Duscher G, Martinek K, Dubinsky P, Guislain MH, Cliquet F, Romig T, Malczewski A, Gottstein B, Piarroux R: Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. Plos Negl Trop Dis 3(6): e452 (2009).
38. Knapp J, Bart JM, Giraudoux P, Glowatzki ML, Breyer I, Raoul F, Deplazes P, Duscher G, Martinek K, Dubinsky P, Guislain MH, Cliquet F, Romig T, Malczewski A, Gottstein B, Piarroux R. Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. PLoS Negl Trop Dis. 2009 Jun 9;3(6):e452.
39. Knapp J, Bart JM, Maillard S, Gottstein B, Piarroux R. The genomic Echinococcus microsatellite EmsB sequences: from a molecular marker to the epidemiological tool. Parasitology. 2010 Mar;137(3):439-49.
40. Knapp J, Guislain MH, Bart JM, Raoul F, Gottstein B, Giraudoux P, Piarroux R: Genetic diversity of Echinococcus multilocularis on a local scale. Infection, Genetics and Evolution 8: 367-373 (2008).
41. Knapp J, J.M. Bart, M.L. Glowatzki, A. Ito, S. Gerard, S. Maillard, R. Piarroux, B. Gottstein: Assessment of microsatellite polymorphism for improving the spatial distribution tracking of Echinococcus multilocularis. J Clinical Microbiology, 45: 2943-2950 (2007)
42. Lobsiger L, Müller N, Schweizer T, Frey CF, Wiederkehr D, Zumkehr B, Gottstein B. An autochthonous case of cutaneous bovine leishmaniasis in Switzerland. Vet Parasitol. 2010 May 11;169(3-4):408-14. Epub 2010 Jan 25.
43. Maillard S, Benchikh-Elfegoun MC, Knapp J, Bart JM, Koskei P, Gottstein B, Piarroux R: Taxonomic position and geographical distribution of the common sheep G1 and camel G6 strains of Echinococcus granulosus in three African countries. Parasitol Res.100: 495-503 (2007).
44. Maillard S, Gottstein B, Haag KL, Ma S, Colovic I, Benchikh-Elfegoun MC, Knapp J, Piarroux R: The tandemly repeated multilocus microsatellite EmsB: a new tool to investigate the genetic diversity of Echinococcus granulosus sensu lato. J Clin Microbiol. 2009 Sep 9. [Epub ahead of print].
45. Maillard S, Gottstein B, Haag KL, Ma S, Colovic I, Benchikh-Elfegoun MC, Knapp J, Piarroux R. The EmsB tandemly repeated multilocus microsatellite: a new tool to investigate genetic diversity of Echinococcus granulosus sensu lato. J Clin Microbiol. 2009 Nov;47(11):3608-16.
46. Mejri N, Gottstein B. Echinococcus multilocularis metacestode metabolites contain a cysteine protease that digests eotaxin, a CC pro-inflammatory chemokine. Parasitol Res. 2009 Oct;105(5):1253-60
47. Mejri N, Hemphill A, Gottstein B. Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review. Parasitology. 2010 Mar;137(3):557-68.
48. Mueller N, Frei E, Nunez S, Gottstein B. Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen. Parasitology, 134: 879-888 (2007).
49. Neuhaus S, Bruendler P, Frey CF, Gottstein B, Doherr MG, Gerber V: Increased parasite resistance and recurrent airway obstruction in horses of a high-prevalence family. J Vet Intern Med. 2010 Jan 22. [Epub ahead of print].
50. Ortega-Mora LM, Gottstein B, Conraths FJ, Buxton D (eds): Protozoal abortion in farm ruminants; Guidelines for diagnosis and control. CAB International, Wallingford, 2007.
51. Porchet MJ, Sager H, Muggli LL, Oppliger A, Müller N, Frey CC, Gottstein B: Etude épidémiologique descriptive de la Babésiose canine dans la Région Lémanique. Schweiz. Arch. Tierheilkd. 149 : 457-465 (2007).
52. Schild M, Gianinazzi C, Gottstein B, Muller N: PCR-based diagnosis of Naegleria spp. infection in formalin-fixed and paraffin-embedded brain sections. J Clin Microbiol. 45: 564-567 (2007).
53. Schuppers ME, Frey CF, Gottstein B, Stärk KDC, Kihm U, Regula G: Comparing the demonstration of freedom from Trichinella infection of domestic pigs by traditional and risk-based surveillance. Epidemiol. Infect., 2010 Jan 13:1-10. [Epub ahead of print].
54. Schweiger A, Ammann R, Candinas D, Clavien PA, Eckert J, Gottstein B, Halkic N, Muellhaupt B, Prinz BM, Reichen J, Tarr PE, Torgerson PR, Deplazes P: Human alveolar echinococcosis after fox population increase, Switzerland. Emerg Inf Dis 13: 878-882 (2007).
55. Sigg L, Gerber V, Gottstein B, Doherr MG, Frey CF. Seroprevalence of Babesia caballi and Theileria equi in the Swiss horse population. Parasitol Int. 2010 Feb 21. [Epub ahead of print]
56. Siles-Lucas M, Merli M, Gottstein B. 14-3-3 Proteins in Echinococcus: Their role and potential as protective antigens. Exp Parasitol. 119: 516-523 (2008).
57. Spicher M, Naguleswaran A, Ortega-Mora LM, Müller J, Gottstein B, Hemphill A: In vitro and in vivo effects of 2-methoxyestradiol, either alone or combinaed with albendazole, against Echinococcus metacestodes. Exp. Parasitol. 119: 475-482 (2008).
58. Spicher M, Roethlisberger C, Lany C, Stadelmann B, Keiser J, Ortega-Mora LM, Gottstein B, Hemphill A: In vitro and in vivo treatment of Echinococcus protoscoleces and metacestodes with artemisinin and artemisinin-derivatives. Antimicrob Agents Chemother. 2008 Jul 14. [Epub ahead of print]
59. Strohbusch M, Müller N, Hemphill A, Greif G, Gottstein B: NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. Parasitology 135:1065-1073 (2008).
60. Strohbusch M, Müller N, Hemphill A, Krebber R, Greif G, Gottstein B: Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. Parasitol Res. 104:1335-1343 (2009).
61. Strohbusch M, Müller N, Hemphill A, Margos M, Grandgirard D, Leib S, Greif G, Gottstein B: Neospora caninum and bome marrow-derived dendritic cells: parasite survival, proliferation and induction of cytokinenexpression. Parasite Immunol. 31:366-372 (2009).
62. Vuitton DA, Gottstein B. Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay. J Biomed Biotechnol. 2010;2010:923193. Epub 2010 Mar 21.
63. Wicht B, de Marval F, Gottstein B, Peduzzi R: Imported diphyllobothiasis in Switzerland: molecular evidence of Diphyllobothrium dendriticum (Nitsch, 1824). Parasitol. 102: 201-4 (2008).